Endocrine Abstracts

Somatostatin receptors (sstr1–5) and dopamine receptor 2 (D2DR) are expressed and co-localized in several endocrine tumors including pituitary adenomas that express both D2DR and various subtypes of somatostatin receptors, depending on the original cell type. Treatment of pituitary adenomas using somatostatin or dopamine analogs targets only one receptor (octreotide/lanreotide mainly sst2, cabergoline D2DR). Association of octreotide and cabergoline showed limited additiv...

Recent progress in molecular genetics has successfully identified multiple causative genes for DSD. Such advance is primarily based on the detection of pathologic mutations on coding sequences. However, genetic disorders can be caused by other mechanisms. Here, I will review such mechanisms that have been identified recently.Aromatase excess syndrome (AEXS) as a model for genomic disorder: AEXS is a rare autosomal dominant disorder characterized by gynec...

While it is well known that hyperthyroidism leads to weight loss, and hypothyroidism is associated with weight gain, there has been an increasing focus on the relationship between thyroid function and body weight in recent years. A moderate elevation of TSH concentrations, which is associated with triiodothyronine (T3) values in or slightly above the upper normal range, is frequently found in obese humans. These thyroid hormone alterations in obesity seem rather a c...

Introduction: Mesenchymal bone marrow cells (BMCs) contain pluripotent progenitor cells, which differentiate into multiple lineages. In a previous study, we reported that adenovirus-mediated forced expression of steroidogenic factor-1/adrenal 4 binding protein (SF-1/Ad4BP), an essential nuclear receptor for steroidogenesis, could transform human BMCs into steroidogenic cells, suggesting a possibility of cell transplantation therapy in patients with steroid deficiency. In this ...

Purpose: The effects of the Great East Japan Earthquake, a life-threatening event, on glycemic and lipid control in type 2 diabetic patients were examined. The influence of the DPP-IV inhibitors on glycemic and lipid levels was studied.Method: Three hundred fifty type 2 diabetes outpatients (age 63 years old) who followed careful diet regimen on a normal condition were divided into the two groups: the administrated group (A group), 175 patients who were ...

Aim: To evaluate dermatologic findings in diabetic and nondiabetic acromegalic patients and compare with nonacromegalic diabetic patients. Also to investigate any possible correlation between skin lesions and colonic and thyroid neoplasms.Materials and methods: Data from dermatologic examination of 32 acromegalic and diabetic nonacromegalic patients were compared. Colonoscopic, ultrasonographic and biochemical findings of acromegalic patients were evalua...

Androgen deprivation therapy (ADT) when used in the treatment of prostate carcinoma produces a severe state of hypogonadism. Several but not all epidemiological studies have reported that there is an increased incidence of cardiovascular disease (CVD) including myocardial infarction, life threatening arrhythmias, diabetes and sudden cardiac death (1). Studies have also shown that ADT causes adverse effects many within three months on several key cardiovascular risk factors. Th...

Abstract unavailable....

Vascularized whole pancreas transplantation is currently the only therapeutic approach consistently able to restore euglycemia in patients with type 1 diabetes. More than two-thirds of all pancreas transplants are performed simultaneously with the kidney (SPK: simultaneous pancreas kidney) in patients with end-stage diabetic nephropathy. The results of SPK transplantation are excellent with rates of insulin-independence >80% at 1 year and >70% at 5 years. Venous thromb...

Abstract unavailable....